在滥用药物中用于样本有效性测试的不同方法的比较,包括pH方法,特异重量方法,TECOTM药物改试卷和氧化剂测定
Ashraf Mina1,2, John Stathopoulos1, Taveet Sinanian1
1NSW Health Pathology, Forensic & Analytical Science Service (FASS), Toxicology Unit, Macquarie Hospital, Sydney, NSW, Australia.
Advances in laboratory medicine
|June 26, 2023
概括
精确的尿样有效性测试对于识别样品改至关重要. 针对特定重量 (SG) 和pH值的自动化化学方法,结合氧化剂测定,为药物滥用测试提供了卓越的准确性和效率.
科学领域:
- 临床化学 临床化学
- 毒理学 毒理学 毒理学
- 分析化学 分析化学
背景情况:
- 尿样验证对准确的药物滥用查至关重要.
- 未能检测到样品改可能导致误诊和不适当的治疗.
- 存在各种方法来评估尿样完整性,包括特定重量 (SG),pH和杂物检测.
研究的目的:
- 为了比较不同的方法来测量尿样中的比重 (SG) 和pH值.
- 评估TECOTM药物改试验条和氧化剂测定用于检测样品改的有效性.
- 为了为可靠的尿样有效性测试的方法选择提供信息.
主要方法:
- 与传统方法 (pH计,SG折射计,测量棒) 相比,SG和pH自动化化学方法的比较.
- 对氧化剂测定与用于 adulterant 检测的测量棒方法进行评估.
- 使用德明回归和F测试进行统计分析,以评估方法一致性和相关性.
主要成果:
- 自动化 SG 化学方法与折射计 (81.9%) 的一致性比测量棒 (64.7%) 更好.
- 自动化 pH 化学方法与 pH 测量仪 (74.3%) 和测量棒 (81.4%) 相一致.
- 氧化剂测定表明与测量棒的良好相关性,用于检测常见的伪造物,如化酸盐,酸盐和漂白剂.
结论:
- 在SG和pH测量中存在显著的方法和仪器依赖的差异.
- 建议用于样本有效性测试的GS和pH的自动化工方法,以及氧化剂测定.
- 这些推方法确保了药物滥用测试的一致性,准确性和更快的周转时间.
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