开发一个风险评分,以识别患有COVID-19严重病程高风险的患者
Josephine Jacob1, Falko Tesch2, Danny Wende3
1InGef - Institute for Applied Health Research Berlin GmbH, Berlin, Germany.
概括
一个新的风险评分,即POINTED评分,可以准确地识别患有严重COVID-19的高风险个体. 这种工具有助于优先考虑易受伤害的群体进行疫苗接种和强剂注射.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 严重的COVID-19课程构成了重大的公共卫生挑战.
- 识别高风险个体对于有效的资源配置和疫苗接种战略至关重要.
研究的目的:
- 开发和验证一个风险评分 (POINTED评分) 以预测严重的COVID-19结果.
- 支持优先考虑易受伤害的患者进行COVID-19 (强剂) 疫苗接种.
主要方法:
- 一项队列研究利用了2020年被诊断患有COVID-19的623,363名德国索赔数据.
- 采用了35个预定义的风险因素的普森回归模型.
- 风险因素被用来创建一个数值得分 (0-20) 与最小至最大的正常化.
主要成果:
- 确定的主要危险因素包括年龄,唐氏综合征,血液癌症治疗,免疫抑制疗法和神经疾病.
- POINTED得分显示出强大的预测有效性,曲线下的面积 (AUC) 为0.889.
结论:
- POINTED评分是一个验证的工具,用于评估个人患有严重COVID-19病变的风险.
- 这一分数可以有效地帮助识别和优先考虑有针对性的干预措施的风险人群.
相关概念视频
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
42
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
42
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Relative Risk
238
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
238
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
Pneumonia III: Complications and Assessment
278
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
278
COPD: Pathogenesis and Clinical Features
365
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
365


