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不同位置的低毒性生物与椎间盘结构性衰竭之间的关联:元分析和系统审查

Xiaolong Chen^1,2, Shibao Lu², Neha Chopra^1,3

¹Spine Labs, St. George & Sutherland Clinical School University of New South Wales Sydney New South Wales Australia.

|June 26, 2023

概括

脊椎间盘 (IVD) 中的微生物殖民与结构性衰竭有关,特别是末板变化. Cutibacterium acnes是首要发现的病原体,尽管证据质量很低.

科学领域:

微生物学微生物学
整形外科整形外科整形外科
脊柱健康脊柱健康

背景情况:

椎间盘 (IVD) 结构性衰竭,包括退化和末盘变化,可以由各种因素引发,如炎症,感染和失生症.
微生物多样性在IVD中的作用及其与磁盘结构衰竭的关联仍然不完全理解.
腰部疼痛 (LBP) 是一种常见的疾病,通常与IVD问题有关.

研究的目的:

为了研究微生物殖民在不同身体部位 (皮肤,IVD,肌肉,软组织,血液) 对IVD结构失灵的影响.
探索微生物殖民和端板变化之间的关系,这是IVD结构失效的关键指标.
确定患有LBP的患者中微生物殖民的流行率.

主要方法:

进行了对25项队列研究的元分析和系统审查.
在四个在线数据库中搜索相关研究.
分析了各种样本来源中的微生物殖民及其与椎间盘退化 (IDD) 和端板变化的联系,使用几率比率 (OR) 和95%信心区间 (CI).

主要成果:

在2419名患有LBP的患者中,微生物殖民的综合流行率为33.2%.
末盘变化的患者表现出更高的磁盘微生物殖民率 (OR = 2.83).
Cutibacterium acnes是主要发现的病原体,在22.2%的病例中存在.

结论:

这次审查发现了低质量的证据,支持微生物盘殖民和端板变化之间的关联.
昆虫菌被确定为主要的病原体.
需要进一步进行高质量的研究,以阐明连接微生物群,失生症,IVD殖民和结构性衰竭的机制.

关键词:

背部疼痛背部疼痛背部疼痛椎间盘退化椎间盘退化这是一个元分析.微生物组是一个微生物组.微生物群的生物失调症 (microbiome dysbiosis) 是一种微生物群的疾病.系统性审查系统性审查

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