对一种新的仿生人造椎间盘的生物机械评估,用于犬子宫尸脊柱
Celien A M Jacobs1, Remco J P Doodkorte2, S Amir Kamali3
1Orthopedic Biomechanics, Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Noord-Brabant The Netherlands.
JOR spine
|June 26, 2023
概括
新型生物仿真人造脊椎间盘 (bioAID) 有效地模仿自然脊柱运动,比融合更好地保持相邻部分的健康. 这种宫椎间盘置换为治疗退化的椎间盘提供了一个有希望的替代方案.
科学领域:
- 生物医学工程 生物医学工程
- 脊柱生物力学 脊柱生物力学
- 整形外科手术 整形外科手术
背景情况:
- 宫椎间盘置换 (CDR) 旨在恢复脊柱运动并预防相邻段疾病 (ASD),与脊柱融合不同.
- 第一代设备难以复制自然磁盘运动.
- 使用水凝和先进材料开发了一种新的仿生人造脊椎间盘 (bioAID).
研究的目的:
- 评估生物AID对狗脊柱运动学的生物力学影响.
- 为了比较生物AID的性能与完整的脊柱和脊柱融合.
主要方法:
- 对六只狗的尸体棘 (C3-C6) 进行了ex vivo生物力学测试.
- 测试涉及在各种负载条件下 (屈曲延伸,横向曲,轴旋转) 完整的,经过生物AID处理的和合的C4-C5段.
- 测量包括相邻水平的运动范围 (ROM),中性区域 (NZ) 和内压力 (IDP).
主要成果:
- 生物AID保持了自然的旋转曲线和类似的NZ与完整的脊柱.
- 在经过生物AID处理的水平上,正常化的ROM与完整的脊柱相当,侧向曲仅略有减少.
- 邻近的细分ROM被生物AID保存,与融合后观察到的运动增加不同.
结论:
- 生物AID成功地模仿了自然椎间盘的运动行为.
- 与脊柱融合相比,它更好地保留了相邻段的动力学.
- 生物辅助剂 (BioAID) 提出了一个有前途的替代方案,用于宫椎间盘替换退化椎间盘.
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