在接受局部5-甲治疗时患者回电的原因:回顾性图表审查
Rohan Singh1, Milaan A Shah1, Steven R Feldman2
1Drs. Singh and Shah are with the Center for Dermatology Research and Department of Dermatology at Wake Forest School of Medicine in Winston-Salem, North Carolina.
The Journal of clinical and aesthetic dermatology
|June 26, 2023
概括
治疗动作性角质炎 (AK) 的5-Fluorouracil (5-FU) 治疗经常会导致诸如红色和灼热等不良事件. 这些副作用比局部TACROLIMUS报告的副作用更严重.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 行动性角质炎 (AK) 是一种常见的癌前皮肤病变.
- 5-Fluorouracil (5-FU) 是一种用于治疗AK的局部化疗剂.
- 对5-FU的不良事件 (AE) 的评估对于患者管理至关重要.
研究的目的:
- 确定与5-FU相关的不良事件的频率和性质.
- 为了比较与5-FU相关的副作用的发生率与局部塔克罗利斯的发生率.
主要方法:
- 进行了回顾性图表审查和患者电话采访.
- 包括在2015年至2021年期间接受了5-FU或局部塔克罗利斯治疗AK的患者.
- 评估了副作用和与皮肤科医生联系的原因.
主要成果:
- 58%的患者报告了5-FU的副作用,最常见的是红色 (38%) 和灼热 (27%).
- 37%的5-FU患者联系了他们的皮肤科医生,通常是关于严重的局部皮肤反应 (LSR) 或药物问题.
- 只有两个接受局部塔克罗利斯治疗的患者联系了他们的皮肤科医生,主要是因为药物获取问题.
结论:
- 在AK患者中,5-FU会导致频繁且往往严重的副作用.
- 5-FU的刺激明显大于局部塔克罗利斯的刺激.
- 通过讨论5-FU风险,LSR严重程度和替代方案,可以改善管理AK治疗结果.
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