低剂量onabotulinumtoxinA使用七点模式皮内注射在中度至无法忍受的初级下腺透症患者:一个单盲,并排随机试验
Doungkamol Siri-Archawawat1, Weeratian Tawanwongsri2
1Dr. Siri-Archawawat is with the Division of Neurology, Department of Internal Medicine, and School of Medicine at Walailak University in Nakhon Si Thammarat, Thailand.
The Journal of clinical and aesthetic dermatology
|June 26, 2023
概括
低剂量芽毒素A (BTX) 对于治疗原发性腹水症 (HH) 和常规剂量一样有效和安全. 两种25-U和50-U剂量都显示了患者的类似结果和疼痛水平.
科学领域:
- 皮肤病学 皮肤病学
- 医学美学 医学美学
- 临床试验 临床试验
背景情况:
- 腹透症 (HH) 显著影响生活质量.
- 对于股性HH的最佳肉毒素 (BTX) 剂量缺乏共识.
研究的目的:
- 为了比较25-U和50-UonabotulinumtoxinA的疗效和安全性,用于中度至不可容忍的初级腹HH.
- 为了评估与不同的BTX剂量相关的疼痛评分,在关HH治疗中.
主要方法:
- 一个单盲,并排的随机试验,比较每位参与者的下中25-U和50-U的onabotulinumtoxinA.
- 使用小粉-和重力测试,以及HDSS,HidroQoL,GSAS和满意度评分进行评估.
主要成果:
- 在25U和50UBTX组之间,在出汗率,超水区域,疾病严重程度 (HDSS),生活质量 (HidroQoL) 或患者满意度方面没有统计学上显著的差异.
- 在两个治疗臂之间,疼痛评分是可比的 (p=0.810).
结论:
- 低剂量甲毒素A (25-U) 的疗效和安全性与常规剂量 (50-U) 的疗效和安全性相提并论,用于初级腹部.
- 在测试的BTX剂量之间没有观察到注射部疼痛的显著差异.
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Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
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