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在COVID-19后的肺栓塞和深静脉血栓塞:基于人口的队列研究中的长期风险
Helen Sjoland1,2, Martin Lindgren1,2, Triantafyllia Toska1,2
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Research and practice in thrombosis and haemostasis
|June 26, 2023
概括
住院治疗COVID-19增加了静脉血栓塞栓症 (VTE),特别是肺栓塞 (PE) 的长期风险. 与一般人群相比,患有轻度COVID-19的个体没有出现长期VTE风险升高.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 静脉血栓栓塞 (VTE),包括肺栓塞 (PE) 和深静脉血栓塞 (DVT),是急性COVID-19的一个公认并发症.
- 然而,在COVID-19感染后,持续的,长期的VTE风险仍然不完全理解.
研究的目的:
- 这项研究旨在调查COVID-19感染后的VTE的长期发病率.
- 这项研究的具体目的是确定住院状态是否影响这种长期风险.
主要方法:
- 一项队列研究比较了2020年1月至2021年9月期间患有COVID-19 (暴露) 的18-84岁的瑞典公民,与没有COVID-19的匹配对照组 (1:5) 相比.
- 结果包括60天,60-180天和180天以后记录的事件VTE,PE和DVT.
- 根据年龄,性别,并发症和社会经济因素进行调整的考克斯回归分析被用于评估风险.
主要成果:
- 在48,861名住院的COVID-19患者中,与对照人群相比,在感染后60-180天之间观察到PE (6.05) 和DVT (3.97) 的显著升高的危险比率 (HRs).
- 在住院患者中,长期 (≥180天) 调整后HR仍然为PE (2.01) 和DVT (1.46) 升高.
- 与未接受住院治疗的COVID-19患者相比,与未暴露的个人相比,PE或DVT风险的长期显著增加没有.
结论:
- 住院治疗COVID-19与持续增加的VTE风险有关,主要是PE,延长超过180天.
- 相比之下,非住院COVID-19感染的个人似乎没有增加VTE的长期风险.
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