儿童的Helicobacter pylori:在杀死虫子之前,先想一想!
1Department of Gastroenterology, Perth Children's Hospital, Hospital Avenue, Nedlands, Perth, WA 6009, Australia.
由于潜在的益处,儿童的Helicobacter pylori (H. pylori) 根除受到质疑. 新出现的证据表明,H. pylori可能会预防慢性疾病,这促使人们重新评估普遍根除策略.
科学领域:
- 医学微生物学 医学微生物学
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 杆菌 (H. pylori) 是胃潰瘍和胃癌的主要原因.
- 全球共识建议在成年人中根除H. pylori,因为潜在的并发症.
- 杆菌感染很普遍,但严重的并发症很少见,特别是在儿童中.
研究的目的:
- 评估儿童常规H. pylori根除的必要性和潜在危害.
- 考虑H. pylori在慢性健康状况中的有益作用的积累证据.
- 重新审视有关H. pylori"测试和治疗"策略的儿科指南.
主要方法:
- 关于H. pylori在慢性疾病中的作用的流行病学和实验室研究的审查.
- 分析当前儿科指导方针及其遵守情况.
- 讨论H. pylori根除风险和儿童群体的益处之间的平衡.
主要成果:
- 越来越多的证据表明,H. pylori可能对各种慢性健康状况有有益影响.
- 严重的H. pylori相关并发症在儿童中很少发生,即使没有治疗.
- 当前的儿科指南经常建议不要采用普遍的"测试和治疗"方法,尽管并不总是遵循.
结论:
- 在儿童中进行常规的H. pylori根除可能会造成更多的伤害而不是好处,考虑到潜在的好处.
- 需要进一步的研究,以了解H. pylori殖民与儿童群体根除的长期影响.
- 对儿童的H. pylori治疗有必要采取更细致的方法,尤其是在没有并发症的情况下.
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