双触发可以提高正常反应者中的euploidy率吗? 一个横截面研究
Sule Yildirim Kopuk1, Zeynep Ece Utkan Korun1, Aysen Yuceturk1
1Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.
International journal of reproductive biomedicine
|June 26, 2023
概括
使用性腺激素释放激素 (GnRH) 激动剂和hCG的双重触发并没有改善试管婴儿受精的妇女的胚胎化率. 这项研究发现,对于正常反应者来说,双触发和hCG-only触发组之间的euploidy率没有显著差异.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 人类胚胎学 人类胚胎学
背景情况:
- 双触发,结合性腺激素释放激素 (GnRH) 模拟物和人类胆管性腺激素 (hCG),已经显示出对特定患者群体的承诺.
- 以前的研究表明,对于成熟卵细胞产量低或空卵泡综合征的女性来说,有好处.
研究的目的:
- 评估双触发 (hCG + GnRH 激动剂) 对胚胎繁体化率的影响.
- 为了确定双触发是否改善了正常反应女性体外受精结果.
主要方法:
- 一项横截面研究包括494名接受受控卵巢刺激的正常反应女性.
- 参与者被分为两个组:hCG触发器 (n=274) 和双触发器 (hCG+GnRHa,n=220).
- 在所有活检胚胎上进行了瘤积分病 (PGT-A) 的植入前遗传测试.
主要成果:
- 总共有1504个胚胎进行了活检 (hCG组的881个,双触发组的623个).
- 在hCG组中,欧体发育率为35.4%,在双触发组中为29.8%.
- hCG组显示每位活检胚胎的euploidy率数量较高 (31.4%对26.5%),但这种差异在统计学上并不显著 (p>0.05).
结论:
- 在正常响应者中为最终的卵泡成熟添加GnRH激素对hCG的激活剂并不能提高胚胎繁体化率.
- 在这个人群中,双重触发并没有显示出与单独hCG相比,euploidy率的显著改善.
- 可能需要进一步的研究来确定从双重触发中受益的特定患者子组.
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