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具有双重向的农业来源的半孔性二氧化纳米颗粒,用于增强癌症治疗通过三疗法治疗癌症通过三疗法

Yu-Ya Huang¹, Zui-Harng Lee¹, Kai-Chi Chang²

¹National Taiwan Ocean University, Department of Bioscience and Biotechnology No. 2, Beining Rd., Zhongzheng Dist. Keelung City 202 Taiwan Republic of China hmlin@mail.ntou.edu.tw +886-2-2462-2192 +886-2-2462-2192.

|June 26, 2023

概括

这项研究开发了新的双重向纳米粒子 (rMSN-EuGd-Bi@CPT-HA-FA),用于增强癌症治疗. 这些纳米粒子结合了化疗,光动力疗法和光热疗法,以改善治疗结果.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

从大米中提取的半孔纳米粒子 (MSN) 为药物输送提供了一个可持续的平台.
开发多功能纳米粒子对于有效的癌症治疗至关重要,它结合了多种治疗方式.

研究的目的:

为癌症治疗设计双目标纳米粒子 (rMSN-EuGd-Bi@CPT-HA-FA).
将化疗,光动力疗法 (PDT) 和光热疗法 (PTT) 整合到一个单一的纳米粒子系统中.
使用叶酸 (FA) 和氨酸 (HA) 进行有针对性的输送.

主要方法:

用叶酸 (FA) 和酸 (HA) 修饰米半孔二氧化纳米颗粒 (rMSNs) 的表面.
化学疗法的坎普托塞辛 (CPT),PDT的Eu3+离子和PTT的Bi的负载.
加入Gd3+离子用于磁共振成像 (MRI) 指导.

主要成果:

开发的纳米粒子 (rMSN-EuGd-Bi@CPT-HA-FA) 对A549癌细胞表现出显著的细胞毒性.
经过15分钟的辐射,观察到大约35%的细胞生存率.
CPT,PTT和PDT的协同效应导致30分钟照射后细胞存活率达到20%.

结论:

新型rMSN-EuGd-Bi@CPT-HA-FA纳米颗粒有效地结合化疗,PDT和PTT用于癌症治疗.
双重向增强了基于纳米粒子的三重疗法的有效性.
这种多功能平台对先进的癌症治疗策略有前途.

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