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腹腔大动脉动脉瘤壁的快速应变映射揭示了异质的模式

Marta Irene Bracco^1,2, Magdalena Broda³, Ulver Spangsberg Lorenzen³

¹Mines Saint-Étienne, University Jean Monnet, INSERM, Sainbiose, Saint-Étienne, France.

Frontiers in physiology

|June 26, 2023

概括

这项研究引入了一种快速的,半自动的超声波分析方法来测量腹腔大动脉动脉瘤壁应变. 该工具有助于评估超出当前直径指南的破裂风险.

科学领域:

生物医学工程生物医学工程
心血管成像 - 心血管成像
医学超声波医学超声波

背景情况:

腹腔大动脉瘤 (AAA) 破裂风险目前使用最大直径进行评估,这是具有有限预测能力的标准.
监测AAA进展和断裂风险对于患者管理至关重要.
需要临床相关的工具来补充现有的AAA指南.

研究的目的:

开发一种快速和半自动的方法,用于后处理动态临床超声波序列,以便在AAA壁中进行生物力学估计.
在B模式图像上绘制横截面应变图,以便更好地理解AAA墙壁力学.
提供一个可以补充当前AAA监测指南的工具.

主要方法:

采用了Sparse Demons算法来跟踪AAA壁运动在2D超声波序列中的心脏周期.
利用辐射基函数对比和差异化来映射周期性菌株.
与模拟的超声波数据验证了跟踪方法,并将应变计算与有限元素方法进行了比较.

主要成果:

半自动分析在不到1.5分钟的时间内处理了每个心脏周期.
墙壁运动跟踪与模拟数据相比,实现了0.22毫米的最大根平均平方误差.
计算的菌株与有限元素方法有很好的一致性,平均差异明显小于图像分辨率.

结论:

开发的方法提供了从临床超声波序列的循环壁菌株的快速和准确的测量.
这种技术显示出作为研究AAA墙壁生物力学的工具的希望.
在患者中观察到的应变模式表明与脊柱的潜在相互作用,需要进一步调查.

关键词:

腹部大动脉动脉瘤腹部大动脉动脉瘤有限元素建模有限元素建模辐射基础函数辐射基础函数压力成像检测压力成像检测超声波B模式电影循环超声波弹性成像超声波弹性成像超声波模拟的超声波模拟.血管壁应变血管壁应变

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