对比不同系统性炎症标记物预测临床结果与非ST段升高心肌梗塞患者的语法得分:一项回顾性研究
Hong Li1, Shuai Meng2, Weiguang Chen3
1Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.
International journal of general medicine
|June 26, 2023
概括
新型系统性炎症 (SI) 生物标志物,包括中性粒细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR),hsCRP-白蛋白比率 (hsCAR) 和SII指数,在非ST段升高心肌梗塞 (NSTEMI) 患者中,与Syntax评分相比,对主要心血管事件 (MACE) 的预测优越.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 肌肉心脏病发作 肌肉心脏病发作
背景情况:
- 合成分数为非ST段升高心肌梗塞 (NSTEMI) 建立.
- 系统性炎症 (SI) 生物标志物如NLR,PLR,hsCAR和SII指数正在冠状动脉疾病中出现.
- 有限研究将SI生物标志物与NSTEMI患者的Syntax得分进行比较.
研究的目的:
- 评估和比较SI生物标志物 (NLR,PLR,hsCAR,SII) 的预测值与语法得分.
- 评估这些标记物与NSTEMI患者6个月主要心血管事件 (MACE) 和整体死亡率的相关性.
主要方法:
- 追溯招募429名接受冠状动脉血管造影 (CAG) 的NSTEMI患者.
- 进行了单变量和多变量逻辑回归分析.
- 用接收器操作特征 (ROC) 曲线分析来比较MACE和死亡率的预测值.
主要成果:
- 在高合成分数的患者中观察到较高的NLR,PLR,hsCAR和SII水平.
- 所有SI指标,但不是Syntax得分,是6个月MACE的独立风险因素.
- 与Syntax评分相比,SI生物标志物对MACE的预测价值更高.
结论:
- 新的SI生物标志物 (NLR,PLR,hsCAR,SII) 在NSTEMI患者中为MACE提供了增强的预测价值.
- 这些SI生物标志物显示了对整体死亡率的可比预测值与Syntax得分相比较.
- SI生物标志物是NSTEMI中风险分层的一个有希望的工具.
相关概念视频
01:30Acute Coronary Syndrome III: Diagnostic Studies
11
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
11
01:27Myocarditis II: Clinical Features and Diagnostic Tests
12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
01:30Acute Coronary Syndrome I: Introduction
33
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
33
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
22
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
22
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
127
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
127
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
204
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
204