成年人中COVID-19免疫反应在接种麻疹-红疹疫苗后
Suwoyo Suwoyo1, Erna Rahma Yani1, Koekoeh Hardjito1
1Health Polytechnic, Ministry of Health, Malang, East Java, Indonesia.
Vacunas
|June 26, 2023
概括
麻疹,疹和红疹 (MR) 疫苗在已经接种了两剂COVID-19疫苗的成年人中没有显著增加SARS-CoV-2免疫球蛋白水平. 在接种疫苗后,抗体水平仍然很低.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 由于COVID-19的流行,需要快速开发和部署疫苗.
- 了解不同疫苗接种计划之间的潜在相互作用对于公共卫生至关重要.
- 麻疹,疹和红疹 (MR) 疫苗接种是一种常见的免疫接种,其对现有的SARS-CoV-2免疫力的影响需要调查.
研究的目的:
- 调查麻疹,疹和红疹 (MR) 疫苗接种对SARS-CoV-2免疫球蛋白水平的影响.
- 在接种疫苗的成年人群中,评估MR疫苗接种后抗SARS-CoV-2IgG和IgM抗体标位的变化.
主要方法:
- 进行了一项带有前后测试设计的准实验性研究.
- 这项研究包括30名成年参与者,他们已经完成了第二剂SARS-CoV-2疫苗.
- 在MR接种疫苗之前和之后测量了针对SARS-CoV-2的免疫球蛋白水平 (IgG和IgM).
主要成果:
- 大多数参与者 (60%) 的IgM水平增加,而46.6%的抗SARS-CoV-2IgG水平增加.
- 对抗SARS-CoV-2抗体IgG和IgM水平的增加,MR疫苗的使用没有显著影响.
- 在接种前和接种后的测试中,观察到的抗体水平的增加通常很低.
结论:
- 以前接种了SARS-CoV-2疫苗的成年人接受MR疫苗接种,在IgG和IgM抗体水平方面引起了最小的免疫反应.
- 这些发现表明,在这个队列中,MR疫苗接种和现有的SARS-CoV-2免疫力之间的交叉反应或协同效应有限.
- 可能需要进一步的研究来探索长期影响和潜在的免疫相互作用.
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