鼻内德克斯梅德托米丁喷雾与鼻内正常盐水喷雾在接受过膜提取用于减轻焦虑症的患者的比较评估:随机对照研究
Mrudula Mulay1, Amit Mahajan1, Navin Shah1
1Vadodara, Gujarat 391760 India Oral and Maxillofacial Surgery, K.M Shah Dental College and Hospital.
Journal of maxillofacial and oral surgery
|June 26, 2023
概括
鼻腔内用德克斯梅德托米丁有效地减少了跨膜提取过程中的焦虑和疼痛. 这种非侵入性镇静方法对于口腔手术患者来说是安全和方便的,没有观察到呼吸道并发症.
科学领域:
- 口腔和牙面部外科手术
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 德克斯梅德托米丁具有剂量依赖的α-2上腺受体选择性,提供镇静和止痛,同时具有血液动力学稳定性.
- 鼻内镇静是一种安全的,非侵入性的,在儿科和成人群体中被广泛接受的药物输送方法.
- 穿膜提取是一种常见的面手术,其中最大限度地减少疼痛和焦虑是手术的关键目标.
研究的目的:
- 为了评估内德克塞梅托米丁喷雾与正常盐水安慰剂相比,在经历过膜提取的患者中缓解焦虑的疗效.
- 在轻微的口腔手术期间评估鼻内德克斯梅德托米丁的镇静和止痛作用.
主要方法:
- 一项前性,双盲,随机对照性研究比较了鼻内德克斯梅德托米丁喷雾剂与正常盐水和安慰剂.
- 评估了患者的镇静 (兰赛镇静量表),止痛 (视觉模拟量表),焦虑,血压,脉率和氧和 (SpO2).
- 评估是在基线和给药后15分钟,30分钟和45分钟进行的,持续到跨膜提取程序.
主要成果:
- 内鼻式德克斯米德米丁的使用没有导致呼吸抑制或相关并发症.
- 在德克斯梅托米丁组和安慰剂组之间观察到镇静和镇痛的显著差异.
- 德克斯梅德托米丁组的脉率和血压显著下降,有助于减少焦虑.
结论:
- 鼻腔内原子化德克斯梅德托米丁 (1.5mcg/kg) 是临床上有效的镇静患者经历过 transalveolar 提取和其他轻微的口腔和面外科手术.
- 这种方法很方便,减少了患者的焦虑,在口腔和面外科手术中使用是安全的.
- 这项研究支持鼻内用德克斯梅德托米丁作为在门诊口腔外科手术环境中镇静和焦虑管理的可行选择.
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