动脉硬及其对大脑形态和认知功能的影响
Melanie Haidegger1, Simon Lindenbeck1, Edith Hofer1,2
1Department of Neurology, Medical University of Graz, Graz, Austria.
Therapeutic advances in neurological disorders
|June 26, 2023
概括
通过脉冲波速度 (PWV) 测量的动脉硬与老年人脑容量减少有关. 夜间PWV特别与大脑缩有关,这突显了它对脑血管健康的重要性.
科学领域:
- 神经科学是一个神经科学.
- 心血管健康 心血管健康
- 老年学是一门学科.
背景情况:
- 通过脉冲波速度 (PWV) 评估的动脉硬性越来越多地与大脑小血管疾病 (SVD),大脑缩和血管痴呆症有关.
- 循环血压波动是已知的终端器官损伤的决定因素,但24小时PWV变化的作用仍然不清楚.
研究的目的:
- 调查动脉硬 (PWV) 和其昼夜变化与社区居住个体的大脑形态和认知功能之间的关联.
- 确定PWV或其变异性是否影响大脑结构和认知表现.
主要方法:
- 来自奥地利中风预防家庭研究的84名老年参与者的前性,基于社区的后续研究.
- 门诊24小时PWV测量,3特斯拉MRI用于白质超强度和大脑体积评估.
- 神经心理测试电池用于在子组中评估认知功能.
主要成果:
- 脉冲波速度 (PWV) 与大脑总体体积的减少显著相关,独立于血压及其变化 (p=0.013).
- 没有发现PWV与大脑SVD或认知障碍标志物之间存在关联.
- 夜间PWV值显示与全球大脑缩有显著的关联 (p=0.005).
结论:
- 动脉硬与社区居住的老年人大脑总体体积减少有关.
- 增加的夜间PWV对大脑缩比白天测量更为关键.
- 动脉硬度的循环变化可能在大脑健康和衰老中发挥重要作用.
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