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用唾液作为一种替代诊断方法来诊断COVID-19的使用

Meutia Wardhanie Ganie¹, Irbah Rea Alvieda Nainggolan¹, Ramadhan Bestari²

¹Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

|June 26, 2023

概括

唾液检测为检测SARS-CoV-2提供了一种可行的替代性鼻抽样. 这种非侵入性方法显示了可比的诊断性能,特别是在COVID-19症状出现的第一周内.

科学领域:

病毒学病毒学
传染性疾病传染性疾病
诊断测试诊断测试诊断测试

背景情况:

大规模人口测试对于控制SARS-CoV-2传播至关重要.
鼻抽样为广泛的COVID-19测试带来了后勤挑战.
研究替代的,非侵入性的样本,如唾液是必不可少的.

研究的目的:

为了评估唾液样本对SARS-CoV-2RNA检测的敏感性和特异性.
为了比较唾液和鼻抽样对COVID-19的诊断准确性.

主要方法:

153名确诊COVID-19的患者被纳入.
同时采集鼻和唾液样本.
在两种样本类型上对SARS-CoV-2进行RT-PCR测试.

主要成果:

唾液灵敏度为81.5%,特异性为76.4%,与鼻口腔抽样相比.
唾液的积极和消极预测值分别为92.3%和54.1%.
在症状出现后4-7天收集的唾液样本中观察到的最高检测率.

结论:

唾液样本表现出与大人的COVID-19诊断中鼻抽样相似的性能.
唾液是COVID-19检测的重要诊断标本,特别是在症状的最初一周.

关键词:

在 COVID-19 疫情中,新冠病毒新冠病毒新冠病毒.诊断诊断诊断诊断诊断印度尼西亚印度尼西亚印度尼西亚这就是SARS-CoV-2病毒.这是唾液.

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