来自德国的慢性HEV感染个体中检测到的子肝炎E病毒菌株的分子特征
Patrycja Klink1, Dominik Harms1, Britta Altmann1
1Department of Infectious Diseases, Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Robert Koch Institute, 13353 Berlin, Germany.
One health (Amsterdam, Netherlands)
|June 26, 2023
概括
子肝炎E病毒 (raHEV) 在患有慢性HEV感染的免疫功能低下患者中被发现. 分子表征揭示了利巴维林治疗后的特定病毒替代,突出显示子是潜在的HEV来源.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 分子流行病学分子流行病学
背景情况:
- 免疫功能低下个体的持续性病毒血常常导致慢性肝炎E病毒 (HEV) 感染.
- 从猪和野猪传播的HEV已被确立,最近有报道子HEV (raHEV) 感染.
研究的目的:
- 从免疫功能低下,慢性感染的心脏移植患者的raHEV菌株进行分子表征.
- 在慢性HEV感染的情况下调查病毒演变和治疗反应.
主要方法:
- 全长HEV基因组放大和下一代测序.
- 遗传学分析和治疗相关替代物的鉴定.
主要成果:
- 隔离的raHEV菌株 (血和便) 与中国的raHEV菌株具有很高的核酸相同性.
- 遗传学分析将这些菌株与其他raHEV分离物相对应.
- 在HEV序列中发现了与利巴维林 (RBV) 相关的替代物 (V1479I,G1634K和K1398R).
结论:
- 子被证实是人类HEV感染的潜在来源.
- 这些发现强调了需要一个健康的方法来理解HEV流行病学.
- 需要进一步的研究来制定有效的预防和控制HEV感染的策略.
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