虚假阴性HCV感染的原因是与水蛋白的干扰
Gemma Recio Comí1, Carmen Molina Clavero1, Sandra Calabuig Ballester2
1Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l'Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain.
Advances in laboratory medicine
|June 26, 2023
概括
结晶球蛋白 (CGs) 可以干扰实验室测试,导致误诊. 这一案例凸显了CG对C型肝炎病毒 (HCV) 血清学的干扰如何导致诊断延迟,强调了迅速识别和预治疗的必要性.
科学领域:
- 临床化学 临床化学
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 结晶球蛋白 (CGs) 是一种蛋白质,在体外 (in vitro) 引起逆冷诱导沉.
- 已知CG会导致分析干扰,导致实验室测试结果不准确.
- 这种干扰可以显著影响患者的诊断和管理.
研究的目的:
- 为了在肝炎C病毒 (HCV) 血清学中呈现出由于冷球蛋白血干扰导致的误诊病例.
- 为了突出实验室测试中冷蛋白所带来的诊断挑战.
- 强调识别和管理低温球蛋白对于准确诊断的重要性.
主要方法:
- 一位患有急性功能衰竭的老年妇女的病例报告.
- 调查冷球蛋白血症和C型肝炎病毒 (HCV) 状态.
- 用预热血清重复对HCV的血清检测,以确认冷球蛋白干扰.
主要成果:
- 这位患者出现了急性功能衰竭,最初被诊断为基本的冷球蛋白血.
- 检测到一个意想不到的阳性HCV病毒载量.
- 用预热血清重复HCV血清学证实了冷球蛋白干扰,揭示了假阴性结果.
- 该患者最终被诊断出患有HCV二次性低血球蛋白血症.
结论:
- 低温球蛋白可以干扰实验室测试,导致诊断挑战.
- 快速识别水晶球蛋白和先处理血清对于防止虚假结果至关重要.
- 准确的诊断和适当的管理条件,如HCV二次性低血球蛋白血症对于患者的结果是必不可少的.
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