一些肝脏和心脏功能测试在伊朗三个族群的SARS-Cov-2患者的多中心研究
Seyed Majid Fatahi1, Hadi Razavi Nikoo2,3, Ali Safarzadeh4
1Khorramabad, Iran Student Research Committee, Lorestan University of Medical Sciences.
Virusdisease
|June 26, 2023
概括
COVID-19可能会影响肝脏和心脏功能,增加死亡风险. 这项研究发现,Fars个体更容易受到COVID-19相关的肝脏和心脏损伤,强调需要有针对性的监测.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
背景情况:
- COVID-19 (冠状病毒疾病2019) 与潜在的肝脏和心血管并发症有关,增加了患者的死亡率.
- 肝酶 (ALT,AST,LDH) 和心脏标志物 (AST,LDH,CPK) 的升高可以分别表明肝脏和心脏损伤.
- 了解这些并发症对于改善COVID-19患者结果至关重要.
研究的目的:
- 为了比较COVID-19患者与健康个体的肝脏和心脏功能参数.
- 评估COVID-19相关器官损伤的临床特征和种族差异.
- 为了研究COVID-19感染与年龄,血糖和肝/心脏酶水平之间的关联.
主要方法:
- 一项涉及366名个人的比较研究,分为COVID-19患者和健康的对照组.
- 检查肝功能参数 (ALT) 和心脏功能参数 (AST,LDH,CPK).
- 评估临床特征,包括年龄,血糖和种族 (Fars个体).
主要成果:
- COVID-19患者的年龄明显大于对照组 (P < 0.001).
- 两组之间血糖,ALT,CPK,LDH或AST水平没有显著差异,除了Fars个体对肝脏和心脏损伤的更高敏感性外.
- 虽然COVID-19患者的平均ALT水平较高,但这种差异在统计学上并不显著 (P = 0.318).
结论:
- COVID-19感染与衰老和潜在的特定种族倾向 (Fars个体) 与肝脏和心脏损伤有关.
- 尽管存在已知的风险,但这项研究没有发现COVID-19患者和对照人群之间大多数测量的肝脏和心脏参数存在显著差异.
- 需要进一步的研究,以充分阐明SARS-CoV-2对心脏和肝功能的影响,并确认特定种族的易感性.
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