导致下呼吸道感染的细菌病原体的抵抗模式:阿勒-叙利亚
Ola Arab1, Rawaa Al-Kayali1, Abdullah Khouri2
1Department of Biochemistry and Microbiology, Faculty of Pharmacy.
Annals of medicine and surgery (2012)
|June 26, 2023
概括
下呼吸道感染 (LRTI) 是一个主要的全球健康问题. 这项研究确定了关键的细菌罪祸首及其耐药性模式,强调了需要谨慎使用抗生素和管理患者风险因素的必要性.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 下呼吸道感染 (LRTI) 是全球死亡的主要原因之一.
- 细菌和抗菌素敏感性概况在地理位置和时间上有所不同.
- 特定于患者的因素可能会影响LRTIs的发生.
研究的目的:
- 为了研究导致LRTIs的细菌的频谱.
- 为了确定这些细菌分离物的抗微生物敏感性概况.
- 为了确定与LRTIs相关的患者相关的风险因素.
主要方法:
- 从疑似LRTI患者收集了268个标本 (支气管洗,腹腔吸入,吐).
- 进行了细菌培养,鉴定和最小抑制度 (MIC) 敏感性测试.
- 收集患者数据以分析风险因素.
主要成果:
- 确定了150种阳性培养物,包括*Acinetobacter baumannii*,*Pseudomonas aeruginosa*和*Klebsiella pneumoniae*.这些培养物被发现.
- 观察到对大多数抗生素的高耐药性,对胆固醇素 (格拉姆阴性) 和皮佩拉西林-塔扎巴克坦 (格拉姆阳性) 的良好的敏感性. 三甲胺-硫甲醇显示了广泛的实用性.
- 在LRTIs和年龄,吸烟,住院,高血压,慢性肺病和癌症之间发现了显著的相关性.
结论:
- *Acinetobacter baumannii*和*Pseudomonas aeruginosa*是占主导地位的多抗药性病原体.
- 经验性抗生素使用有助于抗药性增加.
- 管理策略应解决患者的风险因素,特别是可修改的风险因素.
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