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结膜微生物群和白炎症状得分在患有眼睛粉红病的患者

Burak Mergen¹, Irem Onal, Abdurrahman Gulmez

¹Department of Ophthalmology (B.M., I.O., Y.Y.); Department of Medical Microbiology (A.G.); and Department of Dermatology and Venereology (C.C.), University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Eye & contact lens

|June 26, 2023

概括

眼性粉红病患者有类似的结膜细菌生长,但眼膜更差,白炎得分更高. 阳性培养与更严重的症状相关,表明微生物群.

科学领域:

眼科医生眼科眼科
微生物学微生物学
皮肤病学皮肤病学

背景情况:

眼睛粉红病 (OR) 是一种影响眼睛的慢性炎症状况.
结膜微生物群在OR病变发生中的作用尚未完全理解.

研究的目的:

与健康对照人群相比,研究OR患者的白炎症状得分,膜功能和结膜微生物群之间的关系.
探索结结膜微生物群在眼睛粉红病发展中的潜在作用.

主要方法:

一项试点研究包括33名OR患者和30名年龄/性别匹配的健康对照.
评估了眼破裂时间 (TBUT),席尔默分数和生命影响和满意度白炎指数 (BLISS).
用MALDI-TOF MS进行结合膜细菌培养的分析以进行鉴定.

主要成果:

在OR患者 (39.4%) 和对照患者 (33.3%) 之间,结膜培养阳性度没有显著差异.
OR患者表现出明显更差的TBUT,希尔默得分和更高的BLISS得分.
阳性结膜培养的OR患者的BLISS分数比负性培养患者高.

结论:

结膜微生物群的组成可能在OR患者和对照人群之间有所不同,具有潜在不同的主导物种.
有阳性培养的OR患者出现更严重的白炎症状表明,结膜微生物群在OR病变发生过程中发挥了作用.
需要进一步研究以阐明涉及的具体机制.

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