皮肤电神经场刺激用于耐药儿科周期性吐综合征
Katja Karrento1, Thangam Venkatesan2, Liyun Zhang3
1From the Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.
Journal of pediatric gastroenterology and nutrition
|June 26, 2023
概括
皮肤电神经场刺激 (PENFS) 为儿科循环吐综合征 (CVS) 提供长期缓解. 这种非侵入性疗法显著降低了CVS发作频率,持续时间和儿童的相关残疾.
科学领域:
- 神经学 神经学
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 循环吐综合征 (CVS) 是一种使人虚弱的疾病,通常对标准药物治疗有抗性.
- 儿科CVS由于其耐火性和对儿童发育的影响而带来了独特的挑战.
研究的目的:
- 为了研究耳部穿皮电神经场刺激 (PENFS) 的疗效,作为预防性治疗儿科CVS.
- 评估PENFS对儿童CVS发作频率,持续时间,恶心和残疾的影响.
主要方法:
- 一项前性研究招募了30名患有耐药性心血管疾病的儿童 (8-18岁).
- 受试者接受了6周的耳部PENFS,在基线和延长后续 (4-6个月) 评估结果.
- 严重程度通过发作频率-持续时间得分,恶心,残疾和全球响应调查来衡量.
主要成果:
- 80%的参与者实现了治疗反应,反应的中位持续时间为113天.
- 观察到CVS频率-持续时间得分 (P < 0.0001),恶心 (P = 0.003) 和残疾 (P = 0.001) 的显著减少.
- 在研究期间没有报告任何严重不良事件.
结论:
- 耳部PENFS在患有CVS的儿童中显示出长期的预防性益处.
- PENFS有效地缓解了儿科CVS的主要致残症状,包括发作频率,持续时间和功能障碍.
- 这种非侵入性神经调节技术为耐火性儿科心血管疾病提供了有前途的治疗选择.
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