心血管自主功能和事件 慢性阻塞性肺病 住院治疗 动脉样硬化风险 在社区
David M MacDonald1,2, Yuekai Ji3, Selcuk Adabag4,5
1Pulmonary Section, and.
Annals of the American Thoracic Society
|June 26, 2023
概括
通过心率变化 (HRV) 和正静性低血压 (OH) 来衡量较好的心血管自主功能,与慢性阻塞性肺病 (COPD) 住院治疗的风险降低有关. 这一发现突出了自主神经系统.
科学领域:
- 心血管自主神经系统功能功能
- 肺部医学 肺部医学
- 流行病学 流行病学
背景情况:
- 自主神经系统在慢性阻塞性肺病 (COPD) 结果中的作用还没有得到充分研究.
- 诸如心率变化 (HRV) 和正静性低血压 (OH) 等心血管自主性测量是疾病风险的潜在指标.
研究的目的:
- 调查基线心血管自主神经系统功能和发生COPD住院治疗之间的关联.
- 评估HRV和OH对COPD相关住院病人的预测价值.
主要方法:
- 在社区动脉样硬化风险 (ARIC) 研究队列中使用了Cox比例危险回归.
- 分析了11625名参与者 (1987-2019) 的HRV和OH测量的基线心电图数据.
- 调整以人口统计学,吸烟,肺功能,并发病症和体力活动为准;按空气流阻塞分层.
主要成果:
- 较高的HRV与COPD住院的风险较低有关.
- 高血压的存在和更大的静态血压变化与COPD住院风险增加相关 (高血压的HR:1.5;95%CI:1.25-1.92).
- 在没有基线空气流阻塞的参与者中,相关性更为明显.
结论:
- 改善心血管自主功能预测未来COPD住院治疗的风险降低.
- 由OH表示的自主功能障碍是COPD住院治疗的危险因素.
- 这些发现表明自主神经系统的健康是COPD预后的一个重要因素,特别是在没有先前存在的肺部疾病的个体中.
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