孕产妇接触农药和早产风险:系统审查和元分析
Shiqi Lin1, Jiajia Li1, Xiaojin Yan1
1Institute of Population Research/China Center on Population Health and Development, Peking University, Beijing 100871, China.
Environment international
|June 26, 2023
概括
孕产妇接触农药可能会增加早产风险. 这一系统性审查发现了适度的证据,表明农药度与不利的出生结果有关,这突显了需要进一步研究的必要性.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 孕妇接触农药是一种潜在的妊娠不良结果的危险因素,可能是通过炎症,氧化应激和内分泌干扰.
- 产前接触农药和早产风险之间的联系需要进一步调查.
研究的目的:
- 系统地审查和对人类在怀孕期间接触农药及其与早产和妊娠年龄相关的观察性研究进行元分析.
- 为了评估每增加杀虫剂度十倍的早产风险.
主要方法:
- 搜索了5个英语和3个中文数据库,截至2023年1月.
- 包括的研究测量了孕期母亲生物样本中的农药暴露.
- 使用OHAT风险偏差工具评估研究质量,并使用CHE模型合成证据.
主要成果:
- 农药度增加十倍可能与早产 (OR=1.28) 和妊娠年龄缩短 (β=-0.10) 相关.
- 农药暴露与妊娠年龄缩短有关,当在怀孕期间随时收集样本时 (β=-0.43).
- 对早产的证据信心被评为"中等",对于妊娠年龄的证据信心被评为"非常低".
结论:
- 适度的证据表明,母亲接触农药和早产风险增加之间存在联系.
- 需要进一步研究更大的样本大小,考虑混因素和准确的结果测量.
- 未来的研究应该调查更广泛的农药化合物和怀孕期间敏感性的关键窗口.
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