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向miR-223增强了多发性硬化症患者的髓质衍生抑制细胞抑制活动

Claudia Cantoni¹, Laura Ghezzi², Jasmine Choi³

¹Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, 85013, United States.

Multiple sclerosis and related disorders

|June 26, 2023

概括

在多发性硬化症 (MS) 中,失调的髓质衍生抑制细胞 (MDSC) 影响T细胞功能. 向miR-223可能会增强MDSC免疫抑制,为MS治疗提供超越葡萄皮质激素的新疗法.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
分子生物学分子生物学

背景情况:

多发性硬化症 (MS) 是一种慢性自身免疫性中枢神经系统疾病.
目前的多发性硬化疗法向适应性免疫;先天性免疫向正在出现.
骨髓原抑制细胞 (MDSCs) 是由miR-223.3调节的关键免疫抑制细胞.

研究的目的:

在MS患者中研究MDSC免疫抑制功能.
探索miR-223在MDSC调节中的作用.
评估作为治疗策略向miR-223的潜力.

主要方法:

从健康对照 (HC) 和患有多发性硬化症 (pwMS) 的人群中与CD4+T细胞共同培养MDSC.
在血清中进行细胞因子/化学因子分析的Luminex测定.
在体外miR-223抑制和STAT3表达分析.

主要成果:

在pwMS中,MDSC抑制活性失调,可通过葡萄糖皮质类药物 (GC) 逆转.
在MDSC中,GC降低了miR-223和增加了STAT3.
miR-223抑制增强了MDSC抑制活性,依赖于STAT3.
在MDSC中酸化的STAT3与血清GM-CSF相关.

结论:

miR-223失调有助于MS中改变的MDSC功能.
向miR-223可能会增强MDSC免疫抑制活性.
miR-223代表了MS的潜在治疗标,作为GC的替代品.

关键词:

葡萄糖皮质类药物是什么多发性硬化症是多发性硬化症.来自骨髓细胞的抑制细胞.神经炎症是一种神经炎症.在 miR-22323 中,它是最常见的.

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