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先天性失明并不能保护动物免受与精神分裂症相关的表型的影响
Stephanie M Perez1, Hannah B Elam1, Alexandra M McCoy1
1Department of Pharmacology and Center for Biomedical Neuroscience, UT Health San Antonio, San Antonio, TX, USA; South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA.
Schizophrenia research
|June 26, 2023
概括
出生失明并不能预防精神分裂症. 这项研究发现,失明并没有在动物模型中阻止与精神分裂症相关的行为,并且在盲鼠中惊人地改变了多巴胺活性和昼夜节律.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 1950年代的一项观察表明,先天性失明可能会预防精神分裂症.
- 这种假设提出,失明可以防止精神分裂症的发展.
研究的目的:
- 调查先天性失明是否能预防与精神分裂症相关的现象.
- 为了检查甲基酸甲醇 (MAM) 动物模型中失明的影响.
主要方法:
- 在老鼠中通过核切手术诱导先天性失明.
- 通过行为和电生理学测试,对老鼠进行了精神分裂症样现象的评估.
- 循环节律通过测量皮质水平来评估.
主要成果:
- 失明并没有阻止MAM诱导的精神分裂症相关的表型.
- 对照大鼠的失明改变了行为和多巴胺神经元活动.
- 盲鼠表现出异常的,非循环的皮质水平,表明昼夜节律受到干扰.
结论:
- 失明并不能防止精神分裂症.
- 在盲鼠中观察到的变化很可能是由于昼夜调节受损.
- 这项临床前研究不支持失明能预防精神分裂症的假设.
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