相关实验视频

Updated: Jul 25, 2025

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

肠道微生物群与结直肠癌中抗瘤免疫的相互作用:从理解到应用

Yu-Pei Zhuang¹, Hong-Li Zhou², Hai-Bin Chen³

¹Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, The First Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|June 26, 2023

概括

肠道微生物群影响结肠直肠癌 (CRC) 免疫治疗反应. 了解这种肠瘤相互作用是改善接受免疫检查点抑制剂 (ICI) 的CRC患者治疗疗效的关键.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
微生物组研究微生物组研究

背景情况:

结肠直肠癌 (CRC) 仍然是一个普遍存在的恶性瘤,对当前的免疫疗法反应不足.
免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但在许多CRC患者中显示出有限的疗效.
人们越来越认识到肠道微生物群在调节抗瘤免疫力和免疫治疗结果方面的作用.

研究的目的:

审查肠道微生物群,CRC和抗瘤免疫反应之间的复杂关系.
要突出关键的研究和关于微生物调节CRC中抗瘤免疫力的最新发现.
探索针对CRC免疫疗法的肠道微生物群的机制,治疗潜力和局限性.

主要方法:

综合文献综述,重点研究肠道微生物群对CRC和免疫治疗的影响.
对将肠道微生物组成与宿主免疫反应联系起来的机制研究的分析.
评估当前和未来的策略,以调节肠道微生物群在CRC治疗.

主要成果:

肠道微生物群显著影响CRC中的前瘤和抗瘤免疫反应.
特定的微生物组成与免疫检查点抑制剂 (ICI) 的差异反应有关.
微生物影响的机制包括系统和瘤透免疫细胞的调节.

结论:

更深入地了解肠道微生物群-CRC-免疫相互作用对于改善免疫治疗结果至关重要.
准肠道微生物群为增强抗瘤免疫力和克服CRC对ICI的抵抗提供了一个有希望的途径.
对微生物调制策略的进一步研究可能会扩大受益于免疫治疗的患者人群.

关键词:

结肠直肠癌是一种癌症.我们的肠道微生物群.调制策略的调制策略.瘤免疫系统的免疫力

更多相关视频

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.