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在卵巢切除的老鼠中,胰岛素通过提高B脂肪素来降低肝脂代谢
Pragati Singh1, Mohammad Irshad Reza1, Anees A Syed2
1Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, India.
Biochimie
|June 26, 2023
概括
胰腺素 (PST) 抑制改善了卵巢切除小鼠的代谢并发症,减少了肝硬化和葡萄糖不耐受. 这表明PST在绝经后代谢功能障碍和肠道失调症中起着关键作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 胃肠病学 胃肠病学
背景情况:
- 绝经后的女性容易患肝硬化症,这是代谢并发症.
- 胰岛素 (PST) 已在糖尿病和胰岛素耐药动物中进行研究.
- 在绝经后代谢变化中PST的作用需要进一步阐明.
研究的目的:
- 为了研究胰岛素 (PST) 在卵巢切除的老鼠中发挥的作用,这些老鼠患有高果糖饮食诱导的代谢功能障碍.
- 研究PST抑制对胰岛素抵抗,葡萄糖不耐受,脂质代谢,肝纤维化和肠道微生物群的影响.
主要方法:
- 经过卵巢切除的雌性SD大鼠被食高果糖饮食12周.
- 在14天内内皮管内注射了PST抑制剂.
- 评估胰岛素耐药性,葡萄糖耐受性,身体成分,脂质样本,肝纤维化 (HE,油红色O,尼罗河红色,西里乌斯红色,马森三色染色) 和肠道微生物群.
主要成果:
- 高果糖饮食诱导葡萄糖不耐受,减少生殖荷尔蒙,增加甘油三和肝脂积累在卵巢切除的老鼠.
- 观察到肝纤维化和肠道微生物群的改变.
- 抑制PST降低了肝脏Fetuin B的表达,并改善了肠道微生物的多样性.
结论:
- PST在放松肝脂代谢的调节中起着重要作用,导致更改的Fetuin B表达和绝经后老鼠的肠道失调.
- 抑制PST为管理与更年期相关的代谢并发症提供了潜在的治疗策略.
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