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Updated: Jul 25, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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Published on: September 25, 2017

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布米坦胺作为一种模型NDSRI基质:N-nitrosobumetanide杂质形成及其在布米坦胺片中的抑制

Diaa Shakleya1, Bethel Asmelash2, Alaadin Alayoubi1

  • 1Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Testing and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Journal of pharmaceutical sciences
|June 26, 2023
PubMed
概括

布米坦胺片中的胺类药物物质相关杂质 (NDSRI) 通过性pH或抗氧化剂 (如酸) 减轻. 这项研究研究了减少药物产品中尼托胺形成的方法.

关键词:
亚斯科布酸是一种亚斯科布酸.这就是Bumetanide的意义.咖啡酸是一种咖啡酸.费鲁酸是什么 费鲁酸是什么 费鲁酸是什么缓解缓解缓解的方法这是一种N-nitrosobumetanide.亚酸盐是一种酸盐.稳定的稳定性 稳定的稳定性

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