线粒体固的自组装纳米粒子用于多路径能量耗尽:在化疗-联合饥饿疗法中的"纳米炸弹"
Kexin Zhang1, Jiaxin Zhu2, Ruyi Wang3
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
International journal of pharmaceutics
|June 26, 2023
概括
这项研究开发了一种针对三阴性乳腺癌 (TNBC) 的新型纳米药物,该药物将化疗与能量阻断饥饿疗法结合起来. 这种协同方法针对癌细胞线粒体,有效抑制瘤生长和转移.
科学领域:
- 生物医学工程 生物医学工程
- 纳米医学是一种纳米医学.
- 在瘤学瘤学.
背景情况:
- 由于化疗的有效性有限和严重的副作用,三阴性乳腺癌 (TNBC) 构成了重大的临床挑战.
- 癌症饥饿疗法显示出希望,但受到TNBC的异质性和代谢异常的阻碍.
- 开发具有多种抗瘤机制的协同纳米治疗药物对于改善治疗结果至关重要.
研究的目的:
- 设计和评估混合纳米粒子系统 (BLG@TPGS NPs) 用于TNBC中协同化学饥饿治疗.
- 研究开发的纳米医药的线粒体向能力和多方面代谢抑制.
- 评估化疗和饥饿治疗在抑制瘤增殖,迁移和诱导亡方面的联合疗效.
主要方法:
- 混合BLG@TPGS纳米颗粒的制备,封装了柏柏林 (BBR),隆尼达胺 (LND) 和甘酸 (GA).
- 评估纳米粒子在线粒体中的积累,并通过抑制呼吸,糖解和谷氨酸代谢来诱导能量饥饿.
- 对抗瘤效应的评估,包括增殖抑制,迁移抑制,亡诱导和TNBC细胞中的线粒体分裂 (MDA-MB-231).
主要成果:
- BLG@TPGS NPs证明了有效的线粒体向,在癌细胞的"能源工厂"中积累.
- 这些纳米粒子成功诱导了"三角"饥饿策略,切断了关键的代谢途径.
- 协同效应显著增强了瘤扩散和迁移的抑制,观察到亡和线粒体分裂.
结论:
- 开发的协同作用的化疗联合饥饿纳米药物为TNBC治疗提供了一种创新的,特定于地点的向策略.
- 这种方法通过向线粒体和破坏多个代谢途径,有效地根除癌细胞.
- 该纳米药物显示了提高治疗效率和降低毒性的潜力,为临床TNBC治疗提供了有前途的选择.
相关概念视频
Electron Transport Chain: Complex I and II
14.6K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.6K
The Inner Mitochondrial Membrane
3.5K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria. In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.5K
Mitochondria
13.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.9K
Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K


