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在现场形成的功能性深度浸泡溶剂通过增强界面相互作用来改善粉末的机械性能
Meiling Su1, Maoli Huang1, Zunting Pang1
1School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
International journal of pharmaceutics
|June 26, 2023
概括
深度浸泡溶剂 (DES) 增强了药物粉末的特性. 这项研究表明,DES通过改变界面相互作用来提高Honokiol (HON) 的机械强度和可分片性,从而提供了一种新的绿色制药战略.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 绿色化学 绿色化学
背景情况:
- 深度浸泡溶剂 (DES) 是新兴的绿色溶剂,具有独特的特性,在药品中具有价值.
- 提高粉末的机械性能和可片性对于药物配方至关重要.
研究的目的:
- 调查DES用于提高药物粉末的机械性能和可分片的使用情况.
- 探索负责这些改进的界面交互机制.
主要方法:
- 使用胆化物 (ChCl) 和l-menthol (Men) 合成了两种基于Honokiol (HON) 的新型DES.
- 通过FTIR,1H NMR和DFT计算对DES形成的表征.
- 使用PLM,DSC,固体-液体相图,表面能量分析和分子模拟来评估粉末性能和可表化.
主要成果:
- 在HON粉末中成功地在现场形成了DES.
- 微量DES显著改善了HON的机械性能和可分片性.
- DES促进了固体-液体接口和极性相互作用,增强了粒子间的粘附.
- 离子HON-ChCl DES与非离子HON-Men DES相比,由于更强的键和更高的粘度,显示出更好的改善.
结论:
- DES提供了一种新的绿色策略,用于改善药物粉末的机械性能和药片性.
- 这项研究表明了DES在制药行业的新应用.
- 接口相互作用和键是DES介导性质增强的关键机制.
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