多学会德尔菲关于脂肪肝疾病新命名体系的共识声明
Mary E Rinella1, Jeffrey V Lazarus2, Vlad Ratziu3
1University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA.
Journal of hepatology
|June 26, 2023
概括
专家们倾向于将NAFLD重新命名为与代谢功能障碍相关的脂肪性肝病 (MASLD),因为有耻辱的语言. 新的标准包括心脏代谢风险因素,旨在更好地识别和提高患者的认识.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 代谢障碍 代谢障碍 代谢障碍
- 医学术语 医学术语 医学术语
背景情况:
- 目前NAFLD/NASH的命名法使用排斥性术语和潜在的污名化语言.
- 现有的术语可能会阻碍准确的诊断和患者的理解.
- 需要更新术语,反映当前的科学理解,减少污名化.
研究的目的:
- 评估专家和患者倡导者对改变NAFLD/NASH命名和定义的意见.
- 为了建立一个共识,新的术语和诊断标准的脂肪性肝病.
- 提出一个非污名化和更准确的命名法.
主要方法:
- 一个经过修改的Delphi过程,涉及来自56个国家的236名小组成员,由三个主要的肝脏协会协调.
- 利用4个在线调查和2个混合会议收集专家意见.
- 一个独立的委员会以超级多数 (67%) 的共识为基础完成了建议.
主要成果:
- 74%的受访者支持改变NAFLD/NASH的名称.
- "非酒精" (61%) 和"脂肪" (66%) 被认为是污名化的术语.
- 提出了新的总体术语"稳定性肝病";保留了"稳定性肝炎".
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 被选为NAFLD的替代品.
- 定义更新,包括至少一个心脏代谢风险因素.
- 引入了新的类别"代谢和与酒精有关的/相关的肝病" (MetALD).
结论:
- 建议的命名法 (MASLD) 和诊断标准得到了专家的广泛支持.
- 新的术语是非污名化的,旨在提高疾病意识和患者识别.
- 修订后的命名方便更准确地对与代谢功能障碍和酒精消费相关的肝病进行分类.
相关概念视频
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
146
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
146
01:29Chronic Pancreatitis II: Collaborative Care
116
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
116
01:28Overview of Fatty Acid Metabolism
30.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.8K
01:26Diseases of the Liver and Gallbladder
674
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
674
01:24Chronic Pancreatitis I: Introduction
116
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
116