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在COVID-19患者中,爱斯坦-巴尔病毒重新激活的发生率较高

Keishanne Danielle E Bernal¹, Christopher B Whitehurst²

¹Department of Pathology, Microbiology, and Immunology, New York Medical College, Basic Medical Sciences Building, 15 Dana Rd. Valhalla, NY 10595; Westlake High School, 825 Westlake Dr., Thornwood, NY 10594.

|June 26, 2023

概括

与没有病毒的人相比,COVID-19患者表现出较高的爱斯坦-巴尔病毒 (EBV) 反激活率. 这项研究研究了COVID-19阳性个体与阴性对照对EBV重新激活频率的研究.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

由SARS-CoV-2引起的COVID-19可能导致严重疾病和长期COVID.
在严重的COVID-19和长期COVID患者中,已经注意到爱斯坦-巴尔病毒 (EBV) 的重新激活.
在COVID-19病原发生过程中EBV再激活的作用需要进一步调查.

研究的目的:

确定和比较Epstein-Barr病毒 (EBV) 在患有和没有COVID-19的患者中重新激活的频率.
评估SARS-CoV-2感染和EBV重新激活之间的潜在联系.

主要方法:

分析了来自COVID-19阳性和阴性患者的106个血样本.
检测EBVDNA和对EBV光性基因的抗体,以确定重新激活.
用于EBV基因组检测的定量PCR (qPCR).

主要成果:

在27%的COVID-19阳性患者中检测到EBV重新激活,而在阴性组中为12.5%.
在COVID-19阳性个体中发现了较高水平的SARS-CoV-2核蛋白 (Np).
42.30%的COVID-19阴性组显示过去的SARS-CoV-2感染标志物.

结论:

与非COVID-19患者相比,COVID-19患者的EBV重新激活率显著更高.
这一发现表明SARS-CoV-2感染和EBV重新激活之间的潜在相互作用.
需要进一步的研究,以了解EBV在COVID-19中重新激活的临床影响.

关键词:

在 COVID-19 疫情中,新冠病毒新冠病毒新冠病毒.这是EBV的EBV.爱斯坦-巴尔病毒病毒.再激活重新激活的方法这就是SARS-CoV-2病毒.

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