一个选择性的投射从subthalamic核到帕瓦胺表达型神经元的直体的内神经元
Krishnakanth Kondabolu1, Natalie M Doig2, Olaoluwa Ayeko2
1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102.
eNeuro
|June 26, 2023
概括
甲状腺下核 (STN) 主要针对状体中表达蛋白的内部神经元. 这种选择性连接性表明STN神经元有力地影响条状活动动态.
科学领域:
- 神经科学是一个神经科学.
- 基底性 Ganglia 研究 研究
- 细胞神经科学 细胞神经科学
背景情况:
- 排列体和亚体细胞核 (STN) 是关键的基底性腺核.
- 人们越来越多地认识到STN和条纹体之间的直接联系.
- 了解这些预测的细胞类型特异性至关重要.
研究的目的:
- 为了研究亚thalamostriatal投射的组织和影响.
- 为了确定STN神经元如何与各种条状细胞类型连接.
- 描述条状神经元对STN激活的功能反应.
主要方法:
- 在基因定义的小鼠条纹性群体中单突触逆行追踪.
- 外体生电生理学.
- 光遗传学可以激活STN轴突.
主要成果:
- 在STN神经元中,与其他条状细胞类型相比,对表达parvalbumin的内部神经元的连接性显著更高 (4至8倍).
- 与其他测试类型不同,表达parvalbumin的内部神经元对STN输入有强烈的反应.
- 亚甲腹膜外投影显示了高的向细胞类型选择性.
结论:
- 亚thalamostriatal投射对于表达parvalbumin的内部神经元具有高度选择性.
- 谷氨基性STN神经元可以直接和强烈调节条纹活动.
- 这些内部神经元的丰富内化使STN能够影响条状神经动态.
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