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高压氧和跑步机运动在卵巢切除的老鼠中部分预防了骨损失和骨微型结构恶化
Xiaoling Peng1, Binli Gao1, Xiangxiu Wang2
1Department of Hyperbaric Oxygen, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, People's Republic of China.
Diving and hyperbaric medicine
|June 26, 2023
概括
高压氧 (HBO) 和跑步机运动 (EX) 单独或联合改善了卵巢切除的老鼠的骨密度. 这些疗法可以通过增加抗氧化酶和骨基因表达来对抗骨质疏松症.
科学领域:
- 生物医学科学 生物医学科学
- 运动生理学 运动生理学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 跑步机运动 (EX) 显示对骨质疏松症有好处.
- 高压氧 (HBO) 在体外影响骨质细胞和骨质细胞的形成.
- 对HBO和EX对骨质疏松症的联合作用需要进一步研究.
研究的目的:
- 研究高压氧气 (HBO) 和跑步机运动 (EX) 对卵巢切除小鼠骨质疏松症的影响.
- 评估HBO和EX对骨健康标志物的联合影响.
- 探索治疗效果背后的分子机制.
主要方法:
- 卵巢切除的小鼠被分为五组:对照组,卵巢切除,卵巢切除+EX,卵巢切除+HBO,卵巢切除+HBO+EX.
- 治疗包括每日HBO暴露 (203kPa,85-90%O2,90分钟) 和跑步机运动 (20m/min,40min/day,5°斜率).
- 这两种治疗都在12周内每周五天进行.
主要成果:
- HBO,EX和联合治疗显著增加了骨质细胞相关基因表达和PGC-1α.
- 所有治疗都显著抑制了骨质细胞相关的mRNA (RANKL) 和骨再吸收标志物CTX-I.
- 运动和联合治疗增加了血清中超氧化失调酶 (SOD) 和硬质素的表达.
结论:
- HBO,EX及其组合改善了骨微架构恶化和卵巢切除诱导的骨损失.
- 观察到的骨保护作用可能与增加的SOD活性和PGC-1α上调有关.
- 这些发现表明,使用HBO和运动来治疗骨质疏松症的潜在治疗策略.
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