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患有持续COVID-19症状的患者的神经心理缺陷:系统审查和元分析
Saioa Sobrino-Relaño1, Yolanda Balboa-Bandeira1, Javier Peña1
1Department of Psychology, Faculty of Health Sciences, University of Deusto, Av. de Las Universidades, 24, 48007, Bilbao, Spain.
Scientific reports
|June 26, 2023
概括
长期的COVID可能会导致康复患者显著的认知缺陷. 这一系统性审查证实了持续的脑雾和记忆问题,强调了需要进一步的研究和干预.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 认知科学 认知科学
背景情况:
- 持续的症状,或长期COVID,影响了COVID-19幸存者的很大一部分,可能会在急性感染后很长时间影响认知功能.
- 了解COVID-19的长期神经后果对于患者的康复和公共卫生战略至关重要.
研究的目的:
- 系统地审查和元分析COVID-19急性阶段后个体的认知缺陷.
- 与健康对照人群相比,量化COVID-19后患者的认知障碍程度.
- 提供关于持续的COVID-19相关认知功能障碍现有证据的全面概述.
主要方法:
- 从2020年1月到2021年9月,在多个数据库 (Web of Science,MEDLINE,PubMed,PsycINFO,Scopus,Google Scholar) 进行系统的文献搜索.
- 包括25项研究,其中6项被选择进行元分析,涉及175名康复的COVID-19患者和275名健康对照.
- 使用随机效应模型对认知表现进行比较,以确定效应的大小和异质性.
主要成果:
- 观察到显著的中高效果大小 (g = -0.68,p = 0.02),表明COVID-19后个体的认知缺陷很大.
- 研究中的中等异质性 (I2 = 63%) 表明存在变化,但总体上是一致的发现.
- 与健康的对照组相比,从COVID-19中恢复过来的个人表现出明显的认知表现受损.
结论:
- COVID-19幸存者表现出持续的认知障碍,需要对其长期进展进行进一步调查.
- 迫切需要多学科方法来制定有效的预防策略和针对COVID后认知缺陷的有针对性的康复干预措施.
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