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在老年妇女中,萨尔科佩尼亚不同阶段的炎症生物标志物
Leonardo Augusto da Costa Teixeira1,2, Nubia Carelli Pereira Avelar3, Marco Fabrício Dias Peixoto1
1Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil.
Scientific reports
|June 26, 2023
概括
老年女性的肉症进展与特定炎症生物标志物的水平增加有关,包括BDNF,IL-8,sTNFr-1和sTNFr-2. 这些标记物可能有助于诊断和分阶段萨科佩尼亚.
科学领域:
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 麻症与改变的炎症生物标志物有关,但它们在不同的麻症阶段的行为仍然不清楚.
- 了解这些变化对于有效诊断和治疗老年人肉症至关重要.
研究的目的:
- 为了比较老年妇女的各种各样的炎症生物标志物,跨越萨尔科佩尼亚的各个阶段.
- 为了研究沙尔科佩尼亚严重程度和特定的炎症标志物之间的关系.
主要方法:
- 这项研究包括71名巴西老年女性,评估肌肉力量 (手握),体力表现 (SPPB) 和身体组成 (DEXA).
- 用EWGSOP2标准诊断和分阶段诊断了肉类.
- 从血液样本中分析了一组炎症生物标志物 (IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,TNF,阿迪波涅克丁,莱普丁,抵抗素,BDNF,sTNFr-1,sTNFr-2) 的小组.
主要成果:
- 参与者被分为没有沙科佩尼亚 (45%),可能的沙科佩尼亚 (23.9%),确认的沙科佩尼亚 (19.7%) 和严重的沙科佩尼亚 (11.3%).
- 较高阶段的麻症与BDNF,IL-8,sTNFr-1和sTNFr-2的水平升高相关.
- 对于其他测试的生物标志物,在sarcopenia阶段之间没有观察到显著的变化.
结论:
- 在老年女性中,BDNF,IL-8,sTNFr-1和sTNFr-2水平随着肉症的进展而增加.
- 这些生物标志物显示出在这个人群中诊断和分类肉症严重程度的辅助工具的潜力.
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