NPM1突变通过重塑TAD拓结构来重新编程白血病转录网络

相关实验视频

Updated: Jul 25, 2025

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

32.5K

Qian Lai1,2, Karina Hamamoto2, Huacheng Luo2,3

  • 1Department of Hematology, The First affiliated Hospital of Xiamen University, Xiamen University School of Medicine, Xiamen, 361003, China.

Leukemia
|June 26, 2023
PubMed
概括

核素1 (NPM1C+) 中的C端突变通过通过CTCF定义的拓相关域 (TADs) 改变基因调节,阻止髓分化,驱动急性髓白血病.

更多相关视频

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

8.3K
CRISPR-Mediated Reorganization of Chromatin Loop Structure09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

12.6K

相关概念视频

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
3.0K