肠-大脑轴的多层次分析显示了与自闭症谱系障碍相关的分子和微生物概况
James T Morton1,2, Dong-Min Jin3, Robert H Mills4
1Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
Nature neuroscience
|June 26, 2023
概括
自闭症谱系障碍 (ASD) 涉及肠-大脑轴 (GBA) 干扰. 这项研究将特定的肠道微生物和代谢物与ASD异质性联系起来,揭示了影响大脑基因表达和炎症的GBA功能架构.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,具有多种症状.
- 肠-大脑轴 (GBA) 越来越多地被认为是它在自闭症中的作用,但研究结果缺乏一致性.
- 了解GBA对ASD异质性的影响至关重要.
研究的目的:
- 在多个数据集中识别与ASD相关的分子和微生物概况.
- 研究与ASD表型有关的GBA的功能架构.
- 探索GBA变化,大脑基因表达和ASD饮食模式之间的联系.
主要方法:
- 开发了一种贝叶斯差异性排名算法,用于多原子数据分析.
- 整合了10个微生物组数据集与15个关于饮食,代谢,细胞因子和大脑基因表达的数据集.
- 分析了年龄相匹配,性别相匹配和兄弟姐妹相匹配的队列.
主要成果:
- 确定了与ASD表型异质性相关的GBA功能架构.
- 发现了特定微生物属 (Prevotella,Bifidobacterium,Desulfovibrio,Bacteroides) 和氨基酸,碳水化合物和脂质资料之间的关联.
- 观察到与大脑基因表达,限制性饮食和促炎性细胞因子的相关性.
- 证明了时间微生物组变化与ASD表型之间的联系.
结论:
- 提出ASD多原子GBA调查的框架.
- GBA的功能架构影响ASD异质性,大脑基因表达和炎症.
- 时间微生物组的动态与ASD表型有关.
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