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Updated: Jul 25, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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双重分子间 [4 + 2] 循环添加被糖化酶催化用于天然产品生物合成

Jiawang Liu1, Jiayan Lu2,3, Chen Zhang1

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Nature chemistry
|June 26, 2023
PubMed
概括

两个新型酶,EupfF和PycR1,催化了序列的迪尔斯-阿尔德反应,对于复杂分子生物合成至关重要. 它们的依赖离子的活动,由N-甘氨酸增强,提供了对酶进化和生物催化剂设计的见解.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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