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相关概念视频

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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相关实验视频

Updated: Jun 24, 2026

Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

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可复制的大脑表型关联需要大规模的神经成像数据.

Shu Liu1,2, Abdel Abdellaoui3,4, Karin J H Verweij3,4

  • 1Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. s.liu@amsterdamumc.nl.

Nature human behaviour
|June 26, 2023
PubMed
概括
此摘要是机器生成的。

大规模的神经成像研究对于可靠的脑表型关联至关重要. 增加样本大小或预先选择个体可以显著提高可复制性,减少较小的研究中的错误阳性.

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Last Updated: Jun 24, 2026

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Published on: July 24, 2010

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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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科学领域:

  • 神经成像是一种神经成像.
  • 认知神经科学 认知神经科学
  • 精神病学是一个精神病学.

背景情况:

  • 大脑表型关联的可复制性对于理解个人之间的差异至关重要.
  • 之前的神经成像研究还没有充分解决对可靠发现的样本大小要求.

研究的目的:

  • 为了确定可复制的大脑表型关联所需的样本大小.
  • 调查样本大小和个体预选对可复制性的影响.
  • 评估效果大小与所需样本大小之间的关系.

主要方法:

  • 使用了英国生物银行的神经成像数据集 (N=37,447).
  • 研究了神经成像数据与六个与健康相关的变量之间的关联:年龄,体重指数,智力,记忆,神经病症和酒精消费.
  • 评估了随着样本大小的增加而提高的可复制性,并比较了个体上方和下方四分位数之间的发现.

主要成果:

  • 对于年龄来说,高度可复制的协会需要大约300个个体.
  • 其他表型需要样本大小从1500到3900个个体.
  • 要求的样本大小表明了负权力法与效果大小的关系,预选减少了15-75%的样本大小需求.

结论:

  • 大规模的神经成像数据集对于可重现的大脑表型关联是必要的.
  • 预选参与者可以减轻对极大样本大小的需求.
  • 由于样本规模不足,小规模研究可能容易报告假阳性结果.