在患有Sjögren综合征的患者中,共同存在的初级胆道胆炎的实验室风险因素:一项回顾性研究
Xuan Gao1, Guangzhi Xiao1, Fengfan Yang1
1Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Rd., Xi'an, 710032, Shaanxi, China.
BMC gastroenterology
|June 26, 2023
概括
升高的IgM,高的抗核抗体 (ANA) 标位与细胞质模式,以及积极的抗中心体抗体 (ACA) 是Sjögren患者初级胆道胆炎 (PBC) 的关键指标.
科学领域:
- 自身免疫性疾病是一种自身免疫性疾病.
- 肝病学 肝病学是一种肝病学.
- 类风湿病学 类风湿病学
背景情况:
- 有限的研究存在于患者的实验室发现与共存的原发性胆道胆炎 (PBC) 和Sjögren综合征 (SS).
- 了解这些实验室特征对于诊断和管理这些重叠的自身免疫性疾病至关重要.
研究的目的:
- 调查在被诊断为SS的患者中与PBC共存相关的特定实验室风险因素.
- 确定潜在的生物标志物,以便在SS群体中早期检测PBC.
主要方法:
- 追溯分析82名SS和PBC共存的患者,与82名年龄和性别匹配的SS对照进行比较.
- 两组之间的临床和实验室特征的比较.
- 后勤回归分析以确定SS患者PBC共存的独立风险因素.
主要成果:
- 与只有SS的对照组相比,SS和同时存在的PBC患者的肝酶,免疫球蛋白M (IgM),G2和G3水平显著更高.
- 在SS+PBC组的患者中,更高的百分比呈现出高抗核抗体 (ANA) 标位 (>1:10000),特定的ANA模式 (细胞质,中心体,核膜) 和阳性反中心体抗体 (ACA).
- 后勤回归确定了高IgM,高ANA标位与细胞质模式,和阳性ACA作为PBC在SS患者的独立风险因素.
结论:
- 升高的IgM水平,阳性ACA和高的ANA标位与细胞质模式是SS患者PBC的重要指标.
- 这些发现有助于临床医生在Sjögren综合征患者中早期查和诊断原发性胆道胆炎.
相关概念视频
01:26Diseases of the Liver and Gallbladder
674
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
674
01:17Gastritis-II: Pathophysiology
382
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
382
01:29Chronic Pancreatitis II: Collaborative Care
116
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
116
01:24Chronic Pancreatitis I: Introduction
116
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
116
01:26Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
01:17Chronic Bowel Disorders: Introduction
490
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
490