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从BDNF和Dlx2修饰的神经干细胞中分化的GABAergic神经元可以在脑干中风中恢复中断的神经回路

Xiangyue Tang1, Li Wu1, Juehua Zhu2

  • 1Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang East Road, Guangzhou, 510260, China.

Stem cell research & therapy
|June 26, 2023
PubMed
概括

修改的神经干细胞 (NSCs) 为脑干中风提供了一个有前途的治疗方法. 这些工程细胞分化为所需的神经元,集成到大脑电路中,并恢复神经功能,改善中风后的结果.

关键词:
大脑衍生的神经营养因子大脑干的大脑干Dlx2 在线阅读它具有GABA活性的作用.神经干细胞的神经干细胞一次性中风,中风.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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