外体circRNA:关于癌症进展的新兴见解和潜在的临床应用
Fan Zhang1,2, Jiajia Jiang1,2, Hui Qian2
1Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University, 279 Jingang Road, Zhangjiagang, Suzhou, 215600, Jiangsu, People's Republic of China.
Journal of hematology & oncology
|June 26, 2023
概括
外体循环RNAs (circRNAs) 介导癌症和微环境细胞之间的通信,影响瘤进展和免疫逃逸. 这些稳定分子作为诊断生物标志物和癌症治疗治疗的治疗点具有前途.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 外体循环RNAs (circRNAs) 正在成为瘤微环境中细胞间通信的关键调节者.
- 它们影响癌症的关键特征,如免疫逃脱,血管生成,新陈代谢,耐药性,扩散和转移.
- 非瘤细胞也会释放出影响瘤进展的外体环RNA.
研究的目的:
- 在癌症进展中审查来自瘤和非瘤细胞的外体circRNAs的功能和机制.
- 专注于瘤免疫和新陈代谢中的外体环RNAs的作用.
- 检查外体环RNAs作为诊断生物标记物和临床应用的治疗点的潜力.
主要方法:
- 在癌症中对外体circRNAs的研究的文献综述.
- 分析瘤进展,免疫力和新陈代谢中的外体环RNA功能背后的机制.
- 对外体环RNA的诊断和治疗潜力的评估.
主要成果:
- 外体circRNAs促进癌细胞和微环境组件之间的通信,影响癌症的进展.
- 瘤微环境细胞显著影响癌症的进展和通过外性circRNA释放的免疫逃脱.
- 外体环RNAs表现出稳定性,丰富性和广泛分布,使它们成为液体活检和治疗剂的理想选择.
结论:
- 外体环RNA是癌症进展和免疫调节的关键媒介.
- 它们的稳定性和可访问性使它们成为液体活检的有价值生物标志物.
- 向或利用外体circRNAs为癌症治疗提供了新的治疗策略.
相关概念视频
Overview of Exosomes
2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K
lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K


