系统性硬化症与肺高血压相关的内皮细胞生物标志物
Matthew R Lammi1, Kathleen D Kolstad2, Lesley Ann Saketkoo3
1Louisiana State University Health Sciences Center, University Medical Center-New Orleans, and New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, Louisiana.
Arthritis care & research
|June 27, 2023
概括
潘特拉辛-3 (PTX-3) 可以识别肺高血压 (PH) 风险较低的全身性硬化症 (SSc) 患者. 较低的PTX-3水平表明PH风险降低,并可能有助于在SSc患者中区分前毛囊PH.
科学领域:
- 心血管研究研究心血管研究
- 肺部医学 肺部医学
- 生物标志物发现发现
背景情况:
- 系统性硬化症 (SSc) 患者经常出现先进的肺高血压 (PH),需要改进早期检测方法.
- 内皮功能障碍在SSc-PH的发病过程中起着关键作用.
- 目前对SSc-PH的风险分层需要改进.
研究的目的:
- 调查内皮细胞生物标记物的有用性,包括不对称的二甲基氨基 (ADMA),可溶性内素 (sEng) 和素-3 (PTX-3),用于评估SSc-PH风险.
- 确定这些生物标志物是否能够区分SSc-PH亚组.
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于测量ADMA,sEng和PTX-3水平.
- 分析了四组:健康对照组,SSc-PH患者,PH高风险SSc患者和PH低风险SSc患者.
- 生物标志物水平在不同组之间进行了比较,并根据SSc-PH分类进行了分层 (肺动脉高血压[PAH],左心脏病,间歇性肺病[ILD]).
主要成果:
- 与其他组相比,SSc患者患PH风险较低的PTX-3水平明显较低 (P < 0.003).
- PTX-3在区分PH的低风险和高风险SSc患者方面表现出强的表现 (AUC0.87).
- 与PAH或ILD相关的SSc-PH相比,PTX-3的SSc-PH与左心脏病相关的SSc-PH显著较低 (P<0.01).
- 研究组之间ADMA和sEng没有显著差异.
结论:
- PTX-3作为一个有前途的生物标志物,用于识别SSc.患者的PH风险状况.
- 较低的PTX-3水平可能表明毛囊前PH,需要进一步调查.
- 建议在外部队列中进行验证,以确认这些发现.
相关概念视频
01:30Pulmonary Hypertension: Classification and Pathogenesis
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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
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01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
127