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通过远程C-H激活合成铁素1,3-衍生物

Princi Gupta¹, Suchithra Madhavan¹, Manmohan Kapur¹

¹Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462066, MP, India.

Angewandte Chemie (International ed. in English)

|June 27, 2023

概括

研究人员开发了一种新方法,可以在C(3) 位置直接功能化铁,克服了以前的局限性. 这一突破使得使用可移除的指导组和催化剂精确地选择新型铁素1,3-衍生物的位点合成.

科学领域:

有机金属化学有机金属化学
有机合成有机合成
催化剂是一种催化剂.

背景情况:

传统上很难直接使铁烯环的C3位功能化.
在更具反应性的C(2) 位置上实现C(3) 位点选择性是一个重要的合成挑战.

研究的目的:

开发一种用于单替代铁直接C(3) -H功能化的新方法.
为了在功能化铁衍生物中实现精确的位点选择性.

主要方法:

使用一个易于移除的指导组,用于选址功能化.
采用了 ((II) /单-N-保护的氨基酸联体催化系统.
研究了压力强的12个成员的帕拉达循环中间体的形成.

主要成果:

成功合成了铁素1,3-衍生物,具有广泛的烯酸.
在功能化铁甲基胺方面取得了中等到良好的产量.
证明了精确的C(3) 站点选择性,绕过了C(2) 位置.

结论:

建立了一个强大的和通用的合成协议,以访问以前无法访问的铁化学空间.
开发的方法为制造复杂的铁基分子提供了一条新的途径.
使用可拆卸的定向组和特定的催化系统是实现远端功能化的关键.

关键词:

1,3-不替代的铁.C−H 激活方式远距离功能化的功能化油制成型油制成型油制成帕拉催化剂的催化方法

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