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遗传和环境对小鼠的一次试验条件下情境厌恶的影响

Çınar Furkan İlhan¹, Gonzalo P Urcelay², Sezen Kışlal¹

¹Department of Psychology, Middle East Technical University, Ankara, Turkey.

Genes, brain, and behavior

|June 27, 2023

概括

预期性恶心 (AN) 可以在小鼠中使用条件上下文厌恶 (CCA) 来建模. 异种雌性小鼠的CCA保留比雄性更强,这表明CD1小鼠是研究AN性别差异的有价值模型.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
药理学药理学是指药理学的学科.

背景情况:

预期性恶心 (AN) 是一种主要影响女性患者的化疗副作用.
在动物模型AN中,有条件的背景厌恶 (CCA),但先前背景暴露的作用尚不清楚.

研究的目的:

在小鼠中开发一个CCA范式,以评估背景暴露前效应.
评估CCA发育和保留中的潜在性别差异.
确定CD1和C57BL/6J小鼠对模拟AN的适用性.

主要方法:

条件下文本厌恶 (CCA) 是通过将新文本与LiCl诱导的疾病配对而引起的.
在异种 (CD1) 和同种 (C57BL/6J) 两性小鼠中进行评估.
在背景预暴露后评估CCA的发展和保留.

主要成果:

一个单一的调节试验在CD1小鼠中成功诱导了CCA,但在C57BL/6J小鼠中没有.
之前的背景经验有助于CD1小鼠中CCA的发展.
杂交的雌性小鼠表现出比雄性更长时间和更强大的CCA保留.

结论:

CD1异种小鼠作为预期性恶心 (AN) 的合适的临床前模型.
CCA范式有效地展示了背景暴露前效应和性别差异.
这些发现支持进一步调查AN的基于性别的变异及其临床前建模.

关键词:

预期性的恶心.癌症癌症癌症癌症癌症化疗化疗是一种化学疗法.有条件的上下文厌恶.语境学习是指学习的情境.鼠标鼠标鼠标鼠标一次试验的调节条件.在预曝光之前.性别差异的性别差异.菌株的差异是因为菌株的差异.

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