含有多斯皮伦的口服避孕药用于月经前综合征
1Women's Health, Te Whatu Ora Counties Manukau, Auckland, New Zealand.
The Cochrane database of systematic reviews
|June 27, 2023
概括
含有多斯皮伦的组合口服避孕药 (COCs) 可能会改善月经前症状,但它们也会增加副作用. 需要进一步的研究来确定它们的长期疗效和与其他COC相比的比较益处.
科学领域:
- 妇科 妇科 妇科 妇科
- 药理学 药理学是指药理学的学科.
- 妇女健康 妇女健康
背景情况:
- 月经前综合征 (PMS) 和其严重的形式,月经前失调障碍 (PMDD),影响了许多女性.
- 联合口服避孕药 (COCs) 正在探索缓解症状.
- 含有德罗斯皮伦的COC已被批准用于选择避孕的女性的PMDD治疗.
研究的目的:
- 为了评估含有多斯皮伦的COCs在PMS治疗中的有效性和安全性.
- 评估对月经前症状,情绪和不良事件的影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查.
- 搜索了多个数据库,包括Cochrane,MEDLINE,Embase,PsycINFO. 在这些数据库中进行了搜索.
- 包括RCT比较drospirenone的COC与安慰剂或其他PMS的COC.
主要成果:
- 含有德罗斯皮伦的COCs在改善月经前症状和功能障碍方面显示出低质量的证据.
- 由于不良反应而增加戒断风险 (6-16%vs3%安慰剂).
- 总体较高的副作用 (40-54%vs28%安慰剂),包括乳房疼痛,恶心和月经障碍.
结论:
- 含有德罗斯皮伦的COC可能对PMDD相关的功能障碍有好处.
- 与安慰剂相比,副作用的增加是一个令人担忧的问题.
- 关于长期疗效,对不严重症状的影响以及与替代性COC相比,仍然存在不确定性.
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