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在患有黑色素瘤的患者中,紫外线刺激后黑色素细胞的适应性

Yen-Jen Wang^1,2, Chang-Cheng Chang^3,4,5,6, Yu-Hung Wu^1,7

¹Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Lasers in surgery and medicine

|June 27, 2023

概括

梅拉斯马病变显示过度活跃的黑色素细胞对紫外线无反应,而周围的皮肤则动态地适应. 紫外线辐射主要影响临床皮肤,可能会恶化疹.

科学领域:

皮肤病学皮肤病学
光学成像技术的成像
医学物理医学物理

背景情况:

在紫外线 (UV) 照射后,在疹病变中的活体内黑色素的动态变化仍然未被描述.
了解这些变化对于开发有效的疹治疗非常重要.

研究的目的:

为了研究与邻近的皮肤相比,瘤病变中对紫外线辐射的适应性反应.
为了比较不同面部部位的紫外线诱导的晒反应.

主要方法:

利用实时细胞分辨率全场光学连贯性断层扫描 (CRFF-OCT) 来捕获20名亚洲患者的质瘤病变和危险病变的连续图像.
使用计算机辅助检测 (CADe) 系统与卷积神经网络进行定量黑色素分析和分层分布.

主要成果:

在紫外线暴露之前,瘤病变呈现出较高的黑色素水平和较高的糖果黑色素 (C) 与基底层中检测到的黑色素 (D) 的比率.
紫外线照射后,斑在基底层,特别是右脸上,显示了红糖黑色素和C/D比率的增加.
梅拉斯马病变在紫外线暴露前后的黑色素含量或分布没有显著变化.

结论:

梅拉斯马病变的特征是过度活跃的黑色素细胞具有高的基线C/D比率,显示出对紫外线辐射无反应的固定状态.
佩里里修斯保留了适应能力,对紫外线辐射呈现出动态反应,并增加了 konfetti 黑色素的分泌.
紫外线对瘤的加重作用主要归因于对紫外线敏感的危害,而不是瘤病变本身.

关键词:

在活体中成像成像黑色素是什么黑色素是什么黑色素细胞是黑色素细胞.梅拉斯玛是一种神经性疾病.光学连贯性断层扫描 (optical coherence tomography) 是一种光学连贯性断层扫描技术.皮肤颜色皮肤色素

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