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在早产的成年人中改变了灰白质组织对比度
Benita Schmitz-Koep1,2, Aurore Menegaux1,2, Juliana Zimmermann1,2
1Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich; School of Medicine, Munich, Germany.
CNS neuroscience & therapeutics
|June 27, 2023
概括
在成年人中,早产导致皮质微观结构的持久变化,特别是在中间皮质层. 在非常早产的个体中,这些大脑差异与认知表现和出生因素有关.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 过早分娩可能会影响长期的大脑发育和认知功能.
- 皮层微观结构的改变可能是早产儿神经发育差异的基础.
- 灰白物质信号强度对比 (GWPC) 提供了皮质微观结构的体内测量.
研究的目的:
- 通过脑磁共振扫描,通过使用GWPC来研究早产的成年人皮质组织.
- 为了检查GWPC,出生因素和非常早产成人的认知表现之间的关系.
主要方法:
- 结构性MRI被用来分析GWPC在86个非常早产的成年人和103个26岁的对照中的各种皮层百分位.
- 认知表现使用韦克斯勒成人智商量表 (全尺度智商) 进行评估.
主要成果:
- 在非常早产的成年人中观察到GWPC显著下降的前额,顶额和时关联皮层,主要在右半球,特别是在中层皮层.
- 在非常早产的成年人中,在右侧的半中心叶片中发现了增加的GWPC.
- 额叶和叶皮层的GWPC与出生体重正相关,与通风持续时间负相关;右侧半中心叶GWPC与智商负相关.
结论:
- 广泛的异常GWPC表明在早产后皮质微观结构的持久变化.
- 这些微观结构变化主要影响中层皮层,并对关联皮层和初级皮层产生差异性影响.
- 在非常早产的成年人中,皮质微观结构的改变可能会导致认知差异,并与周围生育因素有关.
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